Hereditary spherocytosis pathogenesis. The function of the rbc is to deliver oxygen from the lungs to the tissues and carbon dioxide from the tissues to the lungs. Once the existence of anemia is established investigate the pathogenesis. Angioid streaks are bilateral narrow irregular lines deep to the retina configured in a radiating fashion emanating from the optic disc which result from breaks in a weakened bruchs membrane. Hereditary spherocytosis is a disorder of the red blood cell membrane leading to haemolytic anaemia.
Pathogenesis of parvoviruses b19 infection. If an adequate history has been taken and a physical examination has been performed the etiology may be obvious and confirmatory studies and appropriate therapy can be undertaken with a minimum of investigation. It is inherited as an autosomal dominant condition often linked to chromosome 8. Anemia is strictly defined as a decrease in red blood cell rbc mass.
B19 is associated with the following erythema infectiosum. Although relatively rare hereditary spherocytosis hs is the most common cause of hemolytic anemia due to a red cell membrane defect. Aplastic crisis in patients with chronic haemolytic anaemias.